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Zou Y, Li H, Graham ET, Deik AA, Eaton JK, Wang W, Sandoval-Gomez G, Clish CB, Doench JG, Schreiber SL

Whilst the resulting fragment hits would be expected to bind with a weaker affinity than HTS hits due to their smaller size, they can show a comparatively better ligand efficiency 25

Intramuscular administration of the iron chelator DFO has been shown to slow cognitive decline in AD patients (282), while high concentrations of MDA and 4-HNEkey lipid peroxidation productsand reduced expression of GPX4 have been detected across multiple brain regions in AD (285)