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Such information will guide the design of in vitro and ex vivo models with relevant exposure concentrations and will assist animal models to reveal relevant molecular targets and cellular mechanisms of the individual components of kava ingredients

It involves the decomposition of H 2 O 2 into water and monodehydroascorbate (MDHA) by ascorbate peroxidase (APX), the reduction of MDHA to ascorbate (AsA) or its disproportionation to dehydroascorbate (DHA) by MDHA reductase (MDHAR), and the reduction of DHA back to AsA by dehydroascorbate reductase (DHAR) using glutathione (GSH)

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These HEVs increase effector T cell infiltration and activity by activating lymphotoxin receptor (LTR) signaling, thereby improving therapeutic efficacy [85]