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The aforementioned glutamine transporters are promising drug targets that can inhibit the uptake of glutamine by tumor cells from the source, block the nutritional and energy sources of tumor cells, and thus weaken the advantage of tumor cells in glutamine competition (Fig

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At ~5382 Da, FOXO4-DRI is above the typical renal filtration threshold (~60 kDa for globular proteins, but much lower for linear peptides), suggesting renal clearance may contribute to elimination