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Retrieved 11 May 2018

In short, MTHFR initiates the conversion of folate (vitamin B9) to its functional form 5-methyltetrahydrofolate 93,94 , which on its turn acts as a coenzyme of methionine synthase for the formation of methionine from homocysteine 93,94

The tetracycline antibiotic minocycline likely affects glutamatergic metabolism in multiple ways, presumably reducing the likelihood of excitotoxicity