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We next pursued a strategy of generating a conditional knockdown mutant

ASN Neuro 4 , e00093 (2012)

More significantly, these comprehensive analyses that generate metabolic profiles represent not only biomarkers for disease but also metabolic maps that can be used to identify specific genes responsible for disease

The strong enrichment of amino acid biosynthesis (vra01230) and related pathways, viz., alanine, aspartate and glutamate metabolism (vra00250), arginine biosynthesis (vra00220), glycine, serine and threonine metabolism (vra00260), and cysteine and methionine metabolism (vra00270), indicates an adaptive accumulation of osmoprotective and stress-responsive amino acids