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Morris GM, Huey R, Lindstrom W, Sanner MF, Belew RK, Goodsell DS et al (2009) AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility

Monitoring PpIX biosynthesis in vivo by real-time FL/PA duplex imaging As oxidative stress is a key to the synergistic effect of IIT and 5-ALA-PDT for enhanced therapeutic efficacy 37,47,48 , we explored the metabolic dynamics of PpIX and O 2 generation to validate the feasibility for PpIX synthesis regulation and optimizing treatment parameters in vivo