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L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy

PMID 7945680

Lets work through a hypothetical example

Nrf2, upon translocating to the nucleus, binds to antioxidant response elements (AREs) located in the promoter regions of various genes ( Figure 3 ) ( Figure 3 4.1 Bioactive compounds boost antioxidant and anti-inflammatory responses by activating Nrf2/KEAP1 signaling to combat mastitis: in vitro evidence It has been well established through in vitro experiments that bioactive compounds can enhance the activation of the Nrf2/KEAP1 signaling pathway