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Weller M, Le Rhun E

Dual inhibition of the MEK-ERK pathway (classical tumor signaling pathway) and Gln metabolism can induce redox stress, as evidenced by reduced mitochondrial membrane potential, elevated ROS levels, and inhibition of Gln degradation, and may be an effective therapeutic strategy for KRAS -driven NSCLC ( KRAS -driven cancer cells bypass the Gln-dependent G1 cell cycle checkpoint and are arrested in s-phase when Gln utilization is inhibited

While gastrectomy eliminates alcohol FPM (91), it is unclear whether this is due to the removal of the gastric source of FPM or the saturation of the hepatic source of FPM by the delivery of alcohol as a bolus (in the absence of the gastric pylorus)

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