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In normal red blood cells, pentose phosphate pathway and glycolysis are enhanced and G6PD is sufficient to produce NADPH efficiently for GSSG reduction and maintenance of GSH pool (311)

And among the proteins that make up the thickened cell envelope, small proline rich proteins, also known as stress-inducible proteins, are expressed that protect keratinocytes from ROS ( Superoxide Dismutase SOD is a highly conserved enzyme, that is abundantly expressed in the cytoplasm of aerobic organisms and plays a fundamental role in protecting cells from oxidative stress