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A few general guidelines to start: The lower your income and thus your tax bracket, the more advantageous it is to pay taxes now and make Roth contributions The younger you are and the more time your money has to grow, the better a Roth 401k is, as it will increase the number of years you can take advantage of totally tax free growth The more you are investing and the less likely you are to need to withdraw your 401k contributions during retirement, the better a Roth 401k can be as there are no required minimum distributions with a Roth 401k, and therefore you can benefit from more years of tax free growth

In some cases, calcifications in the basal ganglia may be present

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