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Site burden compounds this: as trials expand globally, particularly into Asia-Pacific and other emerging markets, sites increasingly switch between different sponsor-specific systems and processes, which industry commentary describes as a central operational risk in 2026 rather than a solved problem

The R tximport package (v1.30.0) was utilized to import the transcript-level quantification results and to summarize the reads at the gene level

Next, multiple correlation coefficients per cell type are aggregated to provide a single value per cell type per single cell

The configuration of Th2 cells is triggered by TCR signaling and IL-4 signaling via STAT6, occurring by epigenetic chromatin rearrangement in the Th2 cytokine bunch while concurrently restricting STAT4 and IL-12 R2 expression (Reiner 2005