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When activated, TLRs and NLRs dimerize and transduce signals via the NF-B and MAP kinase pathways

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This GH/IGF-1 axis drives several key metabolic effects: Increased lipolysis, particularly in visceral fat Improved mitochondrial function Enhanced muscle protein synthesis Reduced hepatic fat accumulation Improved insulin signaling Crucially, tesamorelin preferentially reduces visceral fat , not subcutaneous fat