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gasseri : Lactobacillus gasseri IBD: Inflammatory bowel disease SCFAs: Short-chain fatty acids IL: Interleukin RCD: Regulated cell death ROS: Reactive oxygen species GPX4: Glutathione peroxidase 4 GSH: Glutathione System Xc: The cystine/glutamate antiporter system TCM: Traditional Chinese medicine DSS: Dextran sulfate sodium DAI: Disease activity index TNF-: Tumor necrosis factor- Lcn2: Lipocalin 2 FD-4: FITC-Dextran 4 Muc2: Mucin2 4-HNE: 4-Hydroxynonenal MDA: Malondialdehyde ACSL4: Acyl-CoA synthetase long-chain family member 4 FTH1: Ferritin heavy polypeptide 1 GSH: Glutathione KEGG: Kyoto Encyclopedia of Genes and Genomes MVA: Mevalonic acid IFN-: Interferon gamma PUFAs: Polyunsaturated fatty acids PGs: Prostaglandins References Feuerstein JD, Moss AC, Farraye FA

Silybum marianum total extract, silymarin and silibinin abate hepatocarcinogenesis and hepatocellular carcinoma growth via modulation of the HGF/c-Met, Wnt/-catenin, and PI3K/Akt/mTOR signaling pathways

Wang C, Sadovova N, Ali HK, et al