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Type 1 diabetes is primarily caused by destruction of insulin-producing pancreatic beta cells by autoimmune disease or rarely other causes such as trauma

Since the book was published, there are several new references on persistence from researchers from the NIH, using a technique called xenodiagnosis

In an elegant study comparing genetically identical mice housed in different rooms, the authors discovered that one colony had a colonic mucus layer that was impenetrable by bacteria, while the other colony had the opposite

Growth/differentiation factor-15 (GDF-15) Another potential therapeutic pathway for obesity pharmacotherapies is through the stress-induced cytokine GDF-15, which is expressed in multiple cell types including cardiomyocytes, adipocytes and macrophages [98]