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Thus, in a rat model with optic nerve crush, the agonist of CD200R known as CD200Fc was shown to increase CD200R expression and inhibit CD200 expression, thereby assisting in the neuroprotection of RGCs (222, 223)

When NCOA4 is upregulated, it can increase the intracellular iron pool by mediating ferritinophagy, significantly promoting lipid peroxidation and ferroptosis (Lu et al., 2024)

A recent preclinical study showed the adverse effects of supplemental taurine consumption during adolescence and early adulthood on learning and memory function, suggesting an altered balance between new synapse formation and synaptic pruning during final cortical maturation as a possible mechanism (Brown et al., 2020)

Discovering pluripotency: 30 years of mouse embryonic stem cells