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The binding of urokinase plasminogen activator to its receptor is instrumental for the activation of plasminogen to plasmin an important blood protease implicated in blood clot resolution, which has also been shown to degrade extracellular matrix and has been linked to cancer progression

Peer review Peer review information Nature Cell Biology thanks Claudio Mauro, James Galligan and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Their porous structure and negative surface charge contribute to prolonged residence time by promoting cilia-mediated retention and slowing enzymatic degradation

The impact of continuous positive airway pressure therapy on cardiovascular events in patients with obstructive sleep apnoea: an updated systematic review and meta-analysis