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doi:10.1074/jbc.270.13.7176

However, it was observed that large agglomerates of 117 nm TiO 2 caused higher pulmonary cytotoxicity in the mice inhalation study and more blood DNA damage in gavaged mice than small agglomerates (Murugadoss et al., 2020)

But most of the affected study holds up

On the other hand, metabolic syndrome (MetS) is a constellation of symptoms that implies a higher risk for CVD and type 2 diabetes (T2D), increasing the morbidity and mortality of these patients