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To identify cellular proteins that bind m11, we screened cDNA expression libraries from diverse mouse cell lines and tissues with m11Fc, a fusion protein comprising the extracellular domain of m11 (amino acids 1212) fused to a human IgG1 Fc domain, and identified a cDNA encoding mouse CD44, a transmembrane glycoprotein involved in cell adhesion and signalling 12

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While some participants reported temporary skin lightening after IV infusions, the study found that 32 per cent experienced adverse reactions, including liver dysfunction and even a case of anaphylaxis