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Description

L.MaycoxP

GPX4 inhibitors that act via nitrile oxides exhibit remarkable selectivity for GPX4 and diminished off-target effects compared to chloroacetamide-based GPX4 inhibitors

A decrease in the levels of TNF--induced IKK/ (inhibitor of nuclear factor kappa-B kinase subunit beta), IB (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), and NF-B (nuclear factor kappa beta cells) was noted