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At the same time, tissue inhibitors of metalloproteinases (TIMPs) increase across all tested concentrations

In this review, we summarize our current knowledge about metal-based NPs, including the physicochemical properties affecting their toxicity, mechanisms of their toxicity, their toxicological assessment, the potential strategies to mitigate their toxicity and current status of regulatory movement on their toxicity

Baudouin et al., 2012

The decision to continue, modify or discontinue is made between you and the prescribing physician based on your clinical picture, not based on a headline