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Initial reports that a gain-of-function polymorphism (L503F variant, rs1050152) in SLC22A4 that increased transport efficiency of ergothioneine was associated with increased risk of Crohns disease (Reference Peltekova, Wintle and Rubin56) were subsequently shown to have been confounded by the SLC22A4 gene being in linkage disequilibrium with the interferon regulatory factor 1 ( IRF1 ) gene, which was the locus conferring Crohns disease susceptibility (Reference Huff, Witherspoon and Zhang57)

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Folate production capacity has been studied in various strains of the yeast Saccharomyces cerevisiae and yeast species isolated from environments such as marine and tropic milieus, including fruits, vegetables, fish, and insects, as well as in some bacteria 103,628

2014;349:g4490