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To the best of our knowledge, there is a limited amount of research exploring the connection between serum cotinine and TBS

[ii] Ibid

Acrolein exposure (0.15 M) in the human retinal epithelial cells (ARPE19) significantly increased oxidant levels by decreasing GSH, anti-oxidant enzymes (SOD and GSH-peroxidase), and total and nuclear levels of the antioxidant regulator-Nrf2, coincident with reduced mitochondrial function, suggesting a role for acrolein in retinal damage and age-related macular degeneration