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During this initial hyper-inflammatory phase with associated tissue hypoxia, the PRR (Toll-like receptors) upregulate a number of proliferative pathways such as NF-B, hyper activation of NLRP3 inflammasommes, mitogen-activated protein kinase (MAPK), and mammalian target of rapamycin (mTOR) that trigger the cytokine storm [23,24,25]

Effect of long-chain n-3 fatty acid supplementation on visual acuity and growth of preterm infants with and without bronchopulmonary dysplasia