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Tatsunami R, Oba T, Takahashi K, Tampo Y (2009) Methylglyoxal causes dysfunction of thioredoxin and thioredoxin reductase in endothelial cells

High intracellular levels also keep vitamins C and E in their active states, regulate nitric-oxide signaling for vascular health, and calm the inflammatory pathways that flare during infection or strenuous exercise