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Subsequently, we injected AAV-oe Hk2 to overexpress HK2 into the livers of mice

In both, fat and liver, GH stimulates the synthesis of p85 subunit of PI3K [166] leading to the suppression of p110 subunit activity and, thus, antagonising insulins actions [167]

Growth hormone release is closely coupled to slow-wave sleep, and the broader GHRH literature demonstrates that GHRH signaling can influence sleep-endocrine activity, particularly non-REM and slow-wave sleep parameters in controlled experimental settings [5]