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The symptoms of a vitamin B-12 deficiency may include: Fatigue, weakness Memory loss Depression Confusion Insomnia Shortness of breath Poor sense of balance Vision problems Diarrhoea or constipation Loss of appetite Cognitive functioning problems Beefy, red, smooth and sore tongue Sore mouth and/or bleeding gums Numbness and tingling of hands and feet Loss of hearing and tinnitus Pale, possibly yellowish pallor in light-skinned individuals

These are usually mild and go away over time

The pooled effect size was homogenous ( I 2 = 0%) (Fig

Area of application: Vitamin B 12 deficiency that cannot be corrected through nutrition