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A C-terminal extension includes a fatty acid side chain (C20 diacid) conjugated via a linker to promote strong albumin binding, thereby extending half-life

Few published studies use non-oral routes, so dosing data skews toward higher milligram ranges that compensate for bioavailability losses rather than reflecting the minimum effective concentration at the receptor level

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Patients with more significant GI pathology (documented IBD, severe gastroparesis) may be prescribed up to 500 to 1000 mcg daily under closer physician supervision