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Rat Two- and eighteen-month-old adult lean SpragueDawley rats ( n = 12

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Pro-inflammatory cytokines induce signaling cascades that can lead to downregulation of stabilizing factors such as sonic hedgehog [3, 58], to activation of effector proteins such as matrix metalloproteinases [33], and to the formation of reactive oxygen species [47]

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Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

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The resulting formulation was in clinical trials found efficacious and non-inferior to i.v

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