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A recent analysis using Mendelian randomization showed that genetically predicted homocysteine levels increased the odds of NAFLD.[ref] Related article: NAFLD genes Cardiovascular disease: To answer the question of whether a modestly elevated homocysteine level is causally associated with an increased risk of cardiovascular disease, researchers again used huge genetic data sets and Mendelian randomization to determine causality

Brusa D, Serra S, Coscia M, Rossi D, DArena G, Laurenti L, et al

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In Pitx3-deficient mice, SNc DA neurons fail to express TH, leading to loss of nigrostriatal projections (Hwang et al., 2003