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Adenine and PRPP synthesis is catalyzed by AMP and PPi under the action of adenine phosphoribosyltransferase (APRT), facilitated by a divalent Mg 2+ ion (Huyet et al., 2018)

A.AlsalamehS.MakhzoumT.AdeebS.Al-KattanK.et al (2023a)

This heterogeneity encompasses genetic, phenotypic and microenvironmental variations among cancer cells, resulting in subpopulations with varying treatment sensitivities [386]