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Smart responsive hydrogels overcome this limitation by integrating sensing-response-output functionality, achieved through molecular elements such as dynamic covalent/non-covalent bonds, enzyme-substrate peptides, and external field-responsive units, or gene circuits responsive to specific pathological cues, including pH changes, ROS levels, MMP concentrations, and mechanical stress

These regulatory sequences can include one or more of the following: an enhancer, a promoter, a signal peptide sequence, an intron and/or a polyadenylation sequence

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doi:10.1007/s10620-007-0195-5