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No overall differences in the efficacy or safety of amlodipine and valsartan was observed in this patient population, but greater sensitivity of some older individuals cannot be ruled out

Of note, on the basis of epigenetic modification, another study contextualized the significance of lactate-promoting effects on histone H3K18 lactylation in association with histone H3K9 acetylation in UC management, by increasing MCT-induced macrophage lactate uptake, suppressing NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation, and reducing macrophage pyroptosis induced by caspase-1 expression [129]