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It is well-tolerated in animal and early clinical studies, even at multi-milligram doses [12]

While this effect appears to be related to the magnitude and rapidity of glucose lowering rather than a direct effect of the medication itself, patients with a history of diabetic retinopathy should undergo careful ophthalmologic evaluation before and during treatment, and the potential risks should be weighed against the expected benefits of improved glycemic control

This is common in athletes or individuals with eating disorders

Mechanistic Target: Often utilized in model systems to observe fibroblast migration and soft tissue healing pathways