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Mice were genotyped by PCR using tail biopsies harvested between P10 and P14

In mammalian cells, APE1 also has a unique REDOX function, directing the activity of different transcription factors, thereby affecting gene expression and protein production [22]

The Chronic Pain Cycle In many cases, chronic pain management follows a predictable escalation pattern: short-term relief symptom return escalating intervention increasing side effects Over time, this cycle can contribute to nutrient depletion, impaired detoxification, hormonal disruption, immune suppression, and delayed tissue repair , making pain hardernot easierto resolve