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Pop PK, population pharmacokinetics

Meanwhile, CIH may affect cytokine levels in the TME, such as tumor necrosis factor- (TNF-), interleukin-8 (IL-8), and interleukin-6 (IL-6), through the activation of NF-B (Li et al., 2011)

Thus, dietary Met supplementation alleviated aging-related cognitive decline, which was attributed to enhanced BDNF-TrkB signaling and neuronal signal transmission mediated by the NMDAR pathway, as well as the reduced accumulation of toxins

In breast cancer, CHAC1 overexpression promotes both proliferation and migration, while in ovarian cancer, its impact is primarily restricted to cell migration, with minimal effect on proliferation (Metha et al