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This intrinsic oxidative vulnerability of the brain and growing evidence of neurodegenerative changes associated with many psychiatric syndromes suggests that oxidative damage may be a plausible pathogenic candidate

(Neelakantan et al., 2018) observed that systemic administration of NNMTi to mice with diet-induced obesity markedly attenuated WAT mass and body weight, diminished adipocyte volume, and reduced plasma TC levels

doi: 10.1371/journal.pone.0231136 389 NguyenTStainesDJohnstonSMarshall-GradisnikS