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Knuckle pigmentation is an easily visible and early sign of vitamin B12 deficiency

Direct Nutrient Delivery and Bioavailability Unlike oral intake, which is subject to digestion and first-pass metabolism, intravenous delivery avoids potential absorption hurdles such as gastrointestinal disorders or enzyme deficiencies

These amenable properties demonstrated for the small molecules led us to conduct a proof-of-concept in vivo study in diet-induced obese mice to test the hypothesis that the most potent inhibitor when administered systemically, would reverse obesity by causing substantial loss of body weight and adiposity without causing any observable adverse effects

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