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Coenzyme Q10 and Alpha-lipoic acid (ALA) Coenzyme Q10 (CoQ10) and ALA deficiency may cause headaches due to its essential role in cellular energy production and antioxidant protection

Homocysteine (Hcy), a sulfhydryl-containing non-proteinogenic amino acid, is a metabolic intermediate produced by the demethylation of methionine (Met) in the body and is physiologically essential for processes such as cell cycle progression and maintenance of cellular homeostasis [1]

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Importantly, the GM was determined to be more resilient to the lowered pH than the skin microbiota, likely because the GM are naturally exposed to acidic pH from gastric sections, and the researchers speculated that the dysbiosis they observed resulted from host physiological stress rather than directly from acute acidic exposure