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Certain medications (prostaglandin analogs) increase melanin production in the iris, leading to a gradual darkening of eye color over time

Furthermore, DOX upregulates the expression of key mitochondrial enzymes, including DLAT [78]

Phytomedicine 116, 154864

Nevertheless, additional large-scale, multicenter clinical trials are warranted to establish its long-term therapeutic outcomes and safety profile, while further technical parameter optimization is needed to expand its applicability across diverse patient cohorts