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[17] The three loci where identified gene variants are found are designated: Complement factor H (CFH) on chromosome 1 at location 1q31.3 [36] HTRA serine peptidase 1/Age Related Maculopathy Susceptibility 2 (HTRA1/ARMS2) on chromosome 10 at location 10q26 [34] Complement factor B/complement component 2 (CFB/CC2) on chromosome 6 at 6p21.3 Specific genes [edit] Polymorphisms in genes for complement system proteins: Variation in the genes for the complement system proteins factor H (CFH), factor B (CFB) and factor 3 (C3), among others, are strongly associated with a person's risk for developing AMD