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Hemorrhoids are enlarged or swollen veins around the anus or in the lower rectum that can cause itching, bleeding, and pain, especially during bowel movements

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Both upregulated and downregulated proteins were computed in accordance with each network to conduct a pathway analysis and identify proteins associated with the pathways of interest ( We additionally used the hypothesis strategy GeneMANIA (freely available at to generate hypotheses regarding gene functions, calculate gene lists, and weight genes, the algorithm of which is designed to automatically weight networks based on the relevance to the gene set