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Deviations from optimal pH accelerate degradation, and this effect intensifies at room temperature

Structural optimizations, such as replacing the P2 valine with glycine to form Glutamic acid-Glycine-Citrulline (EGCit) (Figure 7a) or designing a non-linear Exo-EEVCit linker (Figure 7b), have proven effective in resisting neutrophil elastase hydrolysis