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International Review of Psychiatry

Current investigations have demonstrated that GPx7 has potential tumor-suppressive effects in gastric and esophageal adenocarcinoma [57,58,59]

Free heme has also been shown to promote inflammatory gene transcription in macrophages via TLR4 and NLRP3 inflammasome signaling, which have both been implicated in worsened atherosclerosis 72,73,74,75 (Fig