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AstaReal Co., Ltd., Tokyo, Japan) were administered to the treatment and placebo groups, respectively for 12 weeks (from Day 1 of two menstrual cycles before starting controlled ovarian stimulation [COS] until oocyte pick-up [OPU])

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The authors of this study suggested that the signaling pathway linking mGluR4 and osteosarcoma might involve the mGluR4/CBX4/HIF-1 signaling pathway ( Figure 3 ) (88)