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In mice, SFB can protect the host by promoting colonization resistance against a wide array of pathogens in the gut 3,97 and more recently also in the lung 12,13,98 while also exacerbating disease severity in models including autoimmune encephalitis 18 , obesity-induced liver damage 19 , autoimmune arthritis 17,20 , depression 42 , Crohns disease 15 , and autism 16

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However, the study included a small number of participants and a shorter follow up time of only 48 weeks compared to other RCTs studying GLP-1 agonists

Since venous disorders have been linked with RLS, diosmin is a promising possible treatment