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Treatment focuses on stopping the inflammation to prevent further damage

Although Chac2 has also been proposed to function as a GSH-degrading enzyme based on its approximately 50% sequence similarity to Chac1 , it shows about 20-fold lower catalytic efficiency than Chac1 on GSH degradation (20)

Insulin resistance, hyperinsulinemia, dyslipidaemia, and obesity precede the progression to T2D in 7585 % of patients [65], and the presence of MetS increases up to fivefold the risk for T2D compared to individuals without MetS [66, 67]