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However, a substantial proportion of low-risk neuroblastomas with elevated MYCN expressed from a normal MYCN locus, particularly those arising in children younger than 18 months, regress spontaneously (stage 4S disease) by unknown mechanisms even when the disease is metastatic 5

After the initial rapid change in velocity caused by impact to the head Suggested Citation: "2 Neuroscience, Biomechanics, and Risks of Concussion in the Developing Brain." Institute of Medicine and National Research Council

The Lancet 368, 16811688 (2006)

At the same time, it suppresses expression of C-C chemokine ligand 2 (CCL2/MCP-1) and CCL5 (RANTES), which are important chemoattractants for monocytes and macrophages, thereby disrupting the inflammatory microenvironment that supports lesion survival, angiogenesis, and fibrosis (Tesarik et al., 2025)