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In addition, to replace current B-cell depletion therapies, the citrullinated antigen expressed by chimeric autoantibody receptor T cells (CAAR-T) has been used to delete anti-citrulline B cells while preserving protective B cells (84)

Drug Metab Rev 43(2):138151

demonstrated that apigenin significantly decreased levels of androgenic hormones (including estrogen, testosterone, LH, and the LH/FSH ratio) and inflammatory cytokines (TNF- and IL-6) in a PCOS-induced Wistar rat model ( Tetracera potatoria , a plant known for its antioxidant, anti-inflammatory, and hormone-balancing properties, demonstrated beneficial effects against PCOS in female Wistar rats (93)

2,3 A predimerized GHR homodimer interacts with the GH ligand through two binding sites, which have different affinities for the receptor