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When combined with Ipamorelin in dual-pathway research models, the two compounds engage both the cAMP pathway via GHRHR and the calcium signalling pathway via GHS-R1a simultaneously on the same somatotroph cell population producing a synergistic GH pulsatility profile that neither compound achieves independently

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Yingzhao Liu, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Disclosure of interest: Doreen Pommeranz: Nothing to disclose