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Despite these diverse origins, such as metabolic dysfunction, immune attack, toxic exposure or vascular injury, the pathophysiological mechanisms involved tend to converge on a common pathway characterized by inflammation, fibrosis, nephron loss and eventual functional failure [15,16,17,18]

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Yuan L, Zhang H, Liu J, Rubin JB, Cho YJ, Shu HK, et al

Murine salivary glands regenerate after radiationinduced damage via SOX2 The murine salivary gland (predominantly the SMG) has been used extensively to investigate the effects of ionizing radiation (IR) on glandular function and structure, where typical analysis is limited to degenerative responses